The 83-year-old was suffering from chronic obstructive pulmonary disease he attributed to his years of smoking.
Nimoy was hospitalized earlier this week.
Nimoy’s career in show business spanned more than six decades and included stints as a stage actor, television guest star, series regular, and movie veteran. He also directed a handful of films, including the box office hit Three Men and a Baby in 1987.
The New York Times reports that Nimoy is survived by his two children, a stepson, six grandchildren, and one great-grandchild.