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Coumadin and Cannabis: What Happens When You Mix Warfarin & Weed? Coumadin, or warfarin, is a kind of anti-coagulant. It prevents the blood from coagulating, or clotting. Cannabis can also act as an anticoagulant, so patients often wonder, can I use marijuana if I’m taking blood thinners? Usually, yes, but caution should be exercised. Most patients taking blood thinners can use cannabis without ill effects. However, these patients should use caution and consume marijuana under the guidance of an experienced healthcare provider. Here are some of the things to know about mixing weed and blood thinners like warfarin or coumadin.