The call came in just after 3:00 a.m. for a structure fire on the 1900 block of Willamette Street.
When crews arrived they saw the upstairs of a large, two-story house engulfed in flames.
The house is separated into four different units, and all occupants were outside when crews responded.
A total of 33 firefighters were on the scene, which took more than an hour to control.
One firefighter suffered leg injuries and was taken to Riverbend, and another suffered arm injuries and was transported to the University District Hospital.
All of the building’s occupants have been displaced and the Red Cross is on scene to help.
The investigation into the fire’s cause is underway.